Trait #110:

LPA and heart health

Are you at a greater genetic risk of cardiovascular disease?

The science

The depositing of cholesterol from our diet into fatty plaques that line arterial walls can cause blood vessels to narrow and ultimately become blocked. As this limits or even prevents blood flow to vital organs, blocked arteries are often the cause of cardiovascular diseases, including heart attacks and strokes.

One particle which deposits cholesterol into these fatty plaques is Lipoprotein (a), or Lp(a), which is produced by the LPA gene.

Variants of this gene which increase Lp(a) activity have been linked to increased risk of arterial narrowing and consequently cardiovascular diseases.

It's estimated that between 75-90% of the difference in Lp(a) levels between individuals is attributed to genetic factors.

Within the LPA gene, we've identified two risk variants which are independently linked to increased Lp(a) activity.

Research has found that carrying one of these risk variants can increase your risk of coronary heart disease by up to 69% compared to non-carriers.

Carrying both risk alleles, however, increases your risk of coronary heart disease by more than 2.5x that of those who don't carry any of the risk variants.

Trait classifications

The LPA and heart health trait identifies the presence or absence of both LPA risk variants to group our members into one of three trait classifications:

Average cardiovascular disease risk

Moderately increased cardiovascular disease risk

Increased cardiovascular disease risk

Recommended actions

All trait classifications receive a collection of personalised lifestyle, nutrition and exercise-related traits to help our members improve their overall cardiovascular health and reduce their cholesterol levels.

The most popular action followed by our members is to complete 2-3 days of moderate to high intensity resistance exercise each week.

Beyond the combined benefits to cardiovascular health and cholesterol levels, this action will also help to improve overall body composition.

Learn more

Download an example LPA and heart health trait report to preview the insights and actions that you may receive.
*Not personalised - DNA analysis or DNA upload required.

To learn more about the LPA gene variants, Lp(a) and the role of aspirin as a possible treatment, read through the accompanying science blog - our in-house science team produce one for each new trait release.

Discover your personal traits

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From a single saliva sample, you can also discover your personal traits relating to:

Vitamins and minerals requirement

Muscle growth and performance

Sleep quality and duration

Metabolic efficiency

Overeating and obesity risk

Aerobic capacity

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