Another genetic variant we test for in the methionine cycle is in the MTRR gene. MTRR is an enzyme that is necessary for the activation of the MTR enzyme, therefore it is also important in the maintenance of low levels of homocysteine. Methionine production is important as it is crucial for ‘DNA methylation’ - the process by which our genes are turned ‘on’ and ‘off’.


Global population distribution:

Source: 1000 Genome Project. Global averages for both sexes

MTRR: AA

43%

MTRR: GA

41%

MTRR: GG

16%

More about MTRR

The MTRR gene plays a key role in maintaining healthy levels of folate and homocysteine. The gene encodes the MTRR enzyme, which is important for stages in your body's folate and methionine cycles.

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