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One of the genes tested for in the methionine cycle is the MTR gene. Variations of this gene influences how efficiently folate is processed.
Source: 1000 Genome Project. Global averages for both sexes
MTR is an enzyme that is necessary for the conversion of homocysteine to methionine. Methionine production is important as it is crucial for ‘DNA methylation’ - the process by which our genes are turned ‘on’ and ‘off’.