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The MC4R gene is involved in the regulation of appetite.
Source: 1000 Genome Project. Global averages for both sexes
The MC4R gene influences the expression of the MC4R receptor which is found in the brain areas associated with eating regulation. One of the alleles that can be present has been found to cause disordered eating behaviours (e.g. high levels of emotional eating), elevating the likelihood of overeating subsequent weight gain.