The protein angiotensinogen, which is produced by the AGT gene, is one of the initial components of a system which helps regulate blood pressure. It also has associations with skeletal and cardiac muscle growth. Your FitnessGenes result indicates your angiotensinogen levels, susceptibility to develop high blood pressure and the impact on strength/power performance.


 

Global population distribution:

Source: 1000 Genome Project. Global averages for both sexes

AGT: CC

54%

AGT: CT

33%

AGT: TT

13%

More about AGT

THE AGT GENE

This gene codes for the protein angiotensinogen – a component of the Renin-Angiotensin-Aldosterone System (RAAS) which regulates blood pressure. Angiotensinogen is converted to angiotensin-I by the enzyme renin. Angiotensin-I then forms angiotensin-II, catalysed by angiotensin-converting enzyme (ACE). In turn, angiotensin-II influences blood pressure by constriction of the blood vessels and by promoting water and salt retention in the kidneys to limit production of urine (increases the blood volume). Angiotensin II is also known to act as a growth factor that regulates skeletal muscle and cardiac hypertrophy, which makes the AGT gene a candidate to influence strength- and power-related performance. The AGT gene alters the amount angiotensin-II formed it affects blood pressure. The C allele of this gene variant is associated with higher angiotensin levels while the T allele is linked to lower angiotensin levels.

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