We test for a variation of the VEGFA gene linked to levels of the VEGFA molecule in the blood. This molecule is involved in forming new blood vessels as an adaptation to training. These new blood vessels increase the blood supply to muscles, which can improve endurance. FitnessGenes tell you whether you have a version of this gene that has been associated with endurance.
Vascular endothelial growth factor A (VEGFA) is a molecule which is involved in the formation of new blood vessels. New blood vessels form in response to things such as tissue damage or training. With respect to training, it has been shown that in untrained individuals, exercise results in an increase in VEGFA levels and an increase in the number of capillaries (tiny blood vessels) supplying blood to muscles over time. This is an adaptation to exercise, allowing our body to supply more oxygen and nutrients and remove more waste products from a trained muscle.
VEGFA is also thought to have an indirect role in the widening of blood vessels (vasodilation). It is thought to trigger nitric oxide and other molecules that relax blood vessels and this leads to increased blood flow. This will result in a better oxygen and nutrient supply reaching our muscles and will remove more waste products from working muscles.
Source: 1000 Genome Project. Global averages for both sexes