VEGFA

A gene for blood vessel formation

We test for a variation of the VEGFA gene linked to levels of the VEGFA molecule in the blood. This molecule is involved in forming new blood vessels as an adaptation to training. These new blood vessels increase the blood supply to muscles, which can improve endurance. FitnessGenes tell you whether you have a version of this gene that has been associated with endurance.

Vascular endothelial growth factor A (VEGFA) is a molecule which is involved in the formation of new blood vessels. New blood vessels form in response to things such as tissue damage or training. With respect to training, it has been shown that in untrained individuals, exercise results in an increase in  VEGFA levels and an increase in the number of capillaries (tiny blood vessels) supplying blood to muscles over time.  This is an adaptation to exercise, allowing our body to supply more oxygen and nutrients and remove more waste products from a trained muscle.

VEGFA is also thought to have an indirect role in the widening of blood vessels (vasodilation).  It is thought to trigger nitric oxide and other molecules that relax blood vessels and this leads to increased blood flow. This will result in a better oxygen and nutrient supply reaching our muscles and will remove more waste products from working muscles.

You can find more information about the VEGFA gene in our member area at member.fitnessgenes.com where you can also find your results and what this means for you after your DNA has been analyzed by us. Head over to the shop to order your Fitnessgenes DNA analysis and genetic training system

Research

We have fully reviewed the impact of this gene and the genetic variant we analyse as part of our scientific research process. You can access the full citation list on all studies reviewed here.

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