Genetic variations in uncoupling proteins are thought to lead to differences in the efficiency of people's metabolism. We test for variations in the UCP2 and UCP3 genes. UCP3 is mainly expressed in skeletal muscles and is involved in fatty acid metabolism and protecting cells from oxidative damage.
Global population distribution:
Source: 1000 Genome Project. Global averages for both sexes
More about UCP3
Uncoupling by UCPs (uncoupling proteins) have become an important focus for scientists to find ways to fight the world’s obesity problems. Uncoupling is a natural mechanism in the mitochondria where calories are ‘wasted’. All UCP’s have an effect on metabolic rate, and although not all their functions have been elucidated fully, their specific functions are related to where the proteins are expressed. We test for the UCPs where genetic variations have shown to result in significant differences: UCP1, UCP2 and UCP3.