As well as being a marker for good health, a high aerobic capacity enables your body to work harder during prolonged exercise. A variation in the PGC1A gene is associated with greater baseline aerobic fitness.


Global population distribution:

Source: 1000 Genome Project. Global averages for both sexes

PGC1A: GG

57%

PGC1A: GA

33%

PGC1A: AA

10%

More about PGC1A

The PGC1A protein is associated with more aerobic-friendly slow-twitch muscle fibers, conversion of muscle fibers from fast-twitch to slow-twitch and generation of new mitochondria (the energy producers of the cell). The PGC1A protein has also been linked to higher rates of new blood vessel production (angiogenesis).

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