Nitric oxide synthase 3 (coded by the NOS3 gene) is an enzyme that facilitates the production of nitric oxide (NO). NO is involved in the widening of blood vessels by relaxation of the smooth muscle cells within their walls, which increases blood flow. Variations in the NOS3 gene may affect the predisposition for power/strength performance. These variations may also influence the beneficial effects induced by exercise, such as a lowering of blood triglycerides levels. 


Global population distribution:

Source: 1000 Genome Project. Global averages for both sexes







More about NOS3

NOS3 codes for an enzyme that helps make nitric oxide (NO). NO acts to relax smooth muscle cells and dilate blood vessels, which in turn increases blood flow. This could help deliver more oxygen, thus improving your workouts.

Increased blood flow helps to increase the delivery of oxygen and nutrients, and the transport of waste products such as metabolites and carbon dioxide. Good blood flow is also important for the process of recovery after exercising the muscles.

Supplements that are suggested to increase NO have become very popular. However, whether it is possible to increase levels of NO through supplements is still a matter of debate. Have a look below at FitnessGenes’ summary of factors that influence NO levels and advice for how to optimize them.

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