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The MTHFR gene is one of the genes involved in the folate cycle. Variations of this gene influences how efficiently folate is processed.
Source: 1000 Genome Project. Global averages for both sexes
MTHFR is an enzyme that converts dietary folate or folic acid to the active form so it can be used by your body. Folate, or Vitamin B9, is essential for several important bodily functions from DNA repair and methylation; to keeping our nervous systems healthy.