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Variations of the IL6R gene have been associated with metabolic syndrome.
Source: 1000 Genome Project. Global averages for both sexes
The IL6R gene codes for the receptor of the IL6 protein (IL6R) which is found on the surface of cells, as well as circulating in the body. Due to its mobility, IL6R can influence the activity and function of IL6, a molecule involved in pro- and anti-inflammatory responses.