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Variations in the IGFBP3 gene affect the levels of IGFBP-3 and may affect body composition.
The IGF1 hormone promotes cell growth and division and is transported through the blood by a protein coded by the IGFBP3 gene. It protects IGF1 against breakdown and prevents it from binding to its receptor.
Source: 1000 Genome Project. Global averages for both sexes