IGF1 (insulin-like growth factor 1), a hormone that promotes cell growth and cell division in both children and adults, is transported through the blood by a molecule called IGF-binding protein 3 (coded by the IGFBP3 gene). It regulates the activity of IGF1 by protecting it against breakdown and preventing it from binding to its receptor.  Variations in this gene affect the levels of IGFBP-3 and IGF1 and may affect body composition.


  

Global population distribution:

Source: 1000 Genome Project.  Global averages for both sexes

IGFBP3: CC

25%

IGFBP3: AC

43%

IGFBP3: AA

32%

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