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Variants of IGF1 have been associated with benefits for strength performance.
Source: 1000 Genome Project. Global averages for both sexes
IGF1 codes for hormone insulin-like growth factor 1. We test for two variations of the IGF1 gene (IGF1 and IGF1-2) which code for the same protein, but have a slightly different effect on the protein’s function. The expression of this hormone regulates the release of the growth hormone involved in cell growth, proliferation, differentiation, cell survival, and the regulation of glucose, fat and protein metabolism.
Since IGF1 has multiple roles in many processes and tissues, determining the influence of the polymorphisms of the IGF1 gene has been an important topic in science. For example, IGF1 was associated with cardiovascular risk, because of its stimulation of NO. Within skeletal muscle, IGF1 triggered hypertrophic signalling and the switch to glycolytic metabolism. Different genetic variants of the IGF1 gene may influence strength gains and responses to resistance training. Genetic variants have also been associated with fasting blood glucose levels. Finally, studies also showed that administration of external IGF1 improves insulin sensitivity in type 2 diabetics.