The fight-or-flight hormone, adrenaline, functions as a signalling molecule by binding to a protein coded for by the ADBR2 gene (beta-2 adrenergic receptor).  This receptor plays a key role in skeletal muscle, cardiovascular, respiratory, metabolic and hormonal systems. The ADRB2_2 genetic variations are associated with obesity and the effect of weight loss interventions.


    

Global population distribution:

Source: 1000 Genome Project.  Global averages for both sexes

ADRB2_2: GG

5%

ADRB2_2: CG

64%

ADRB2_2: CC

31%

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