The IL6R gene codes for the receptor of the interleukin 6 protein (IL6R) which is found on the surface of cells, as well as circulating freely around the body.  Due to its mobility, IL6R can influence the activity and function of interleukin 6, a molecule involved in pro- and anti-inflammatory responses.  Variations of the IL6R gene have been associated with the metabolic syndrome.


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Global population distribution:

Source: 1000 Genome Project. Global averages for both sexes

IL6R: CC

10%

IL6R: CA

38%

IL6R: AA

52%

More about IL6R

THE IL6R GENE

The IL6R gene codes for the Interleukin 6 (IL6) receptor which is a protein that binds IL6 and activates many cellular processes. IL6 is a cytokine that is involved in inflammatory responses within the immune system, and in the regulation of metabolic, regenerative, and neural processes.

In response to infection, inflammation, or trauma, cytokine IL6 plays a role in pathophysiological responses of the immune system, mainly as the first line of defence, and it minimises the level of damage caused by these stimuli.

In muscles and adipose tissue, the release of IL6 has both pro and anti-inflammatory impacts and is an essential component for muscle repair, may contribute to hypertrophy, and could be involved in glucose and lipid metabolism.

Ciliary neurotrophic factor (CNTF) can also interact with the IL6 receptor, contributing to the regulation of cell growth and differentiation within the nervous system. The variant we test for of the CNTF gene has been linked to muscle strength and also appetite regulation.

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