Genes that impact homocysteine levels

Folate, or folic acid, is usually something we associate with pregnant women, but might it have important consequences for you too? The role of folate in red blood cell production and tissue repair makes it a particularly important vitamin for athletes, bodybuilders and fitness enthusiasts. Folate deficiency can also increase homocysteine levels in the blood, which is an indicator of certain health issues. Your FitnessGenes result tells you whether you carry any genetic variations which affect the folate pathways in your body.

Vitamin B9, commonly known as folate, is an essential B-vitamin that performs several important functions in our bodies, from DNA repair and methylation, to keeping our nervous system healthy. You might be more familiar with the term folic acid than folate. These are often used interchangeably and are essentially the same nutrient. The only difference is that folate is the natural form found in foods and folic acid is the synthetic form you find in supplements and fortified foods.

The folate-related genetic variants we analyse impact on a number of steps in the folate and methionine cycles, which can have a direct impact on important muscle-building processes such as DNA synthesis, methylation and red blood cell production. They can also lead to the build up of homocysteine. High levels of homocysteine in our bodies are not good for optimal health. As such, it is important that we preserve healthy levels of this amino acid by maintaining the right balance in the folate and methionine cycles.

You can find more information about the FOLATE gene in our member area at where you can also find your results and what this means for you after your DNA has been analyzed by us. Head over to the shop to order your Fitnessgenes DNA analysis and genetic training system


We have fully reviewed the impact of this gene and the genetic variant we analyse as part of our scientific research process. You can access the full citation list on all studies reviewed here.

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