Many gene variants have been reported to affect the sleep cycle or the circadian clock. Variants of the CLOCK gene are associated with a disturbed circadian rhythm.

Global population distribution:

Source: 1000 Genome Project. Global averages for both sexes

Global population distribution:

Source: 1000 Genome Project. Global averages for both sexes

CLOCK: CC

7%

CLOCK: CT

32%

CLOCK: TT

61%

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