AMPD is an enzyme that plays a role in anaerobic capacity and leads to fast accumulation of lactate after sprint exercises. We test for a genetic variation (AMPD1) that has been linked to different levels of this enzyme. One variation leads to lower levels of AMPD and has been found less frequently in strength/power athletes.


 

Global population distribution:

Source: 1000 Genome Project. Global averages for both sexes

AMPD1: GG

92%

AMPD1: GA

7%

AMPD1: AA

1%

More about AMPD1

AMPD1 GENDER AND ETHNICITY DIFFERENCES

There are gender differences in the activity of AMPD in skeletal muscle. Males appear to have higher AMPD activity compared to females, regardless of genotype. Women who have two copies of the G allele or one G allele only demonstrate 85-88% of the AMPD activity levels noted in males of the same genotype. The rare allele – A – is almost non-existent within Asian and African populations but it is more commonly seen in European populations compared to the global averages. This allele is associated with reduced AMPD activity, with as large as a 55% reduction observed in some studies.

Need help choosing a plan?

Use our Plan Advisor to determine which genetically tailored diet and exercise program best fits your needs.

Find out