The fight-or-flight hormone, adrenaline, functions as a signalling molecule by binding to a protein coded for by the ADBR2 gene (beta-2 adrenergic receptor). This receptor plays a key role in skeletal muscle, cardiovascular, respiratory, metabolic and hormonal systems. ADRB2_1 genetic variations are related to levels of the ADBR2 receptor.


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Global population distribution:

Source: 1000 Genome Project.  Global averages for both sexes

ADRB2_1: GG

28%

ADRB2_1: AG

48%

ADRB2_1: AA

24%

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